Synthesis of bicyclic enediynes that possess a photosensitive triggering device and exhibit strong DNA cleaving activity.

نویسندگان

  • Hiroshi Tanaka
  • Yoshikazu Tanaka
  • Masafumi Minoshima
  • Sho Yamaguchi
  • Shinichiro Fuse
  • Takayuki Doi
  • Susumu Kawauchi
  • Hiroshi Sugiyama
  • Takashi Takahashi
چکیده

The synthesis of a bicyclic enediyne capable of photosensitive triggering and conjugated to a pyrrole-imidazole polyamide is described. Using UV irradiation, this hybrid molecule is shown to exhibit 100-fold stronger potency for DNA cleavage, in an in vitro assay, as compared to the enediyne without the DNA-localizing pyrrole-imidazole.

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عنوان ژورنال:
  • Chemical communications

دوره 46 32  شماره 

صفحات  -

تاریخ انتشار 2010